Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
genetic_interaction_weighted ct 1668 0.0 1.0 0.328 0.272
genetic_interaction_weighted el 1668 0.0 1.0 0.329 0.274
genetic_interaction_weighted ka 1668 0.002 1.0 0.606 0.414
genetic_interaction_weighted rf 1668 0.0 1.0 0.326 0.273
protein_interaction ct 1664 0.0 0.895 0.029 0.068
protein_interaction el 1664 0.0 0.896 0.093 0.134
protein_interaction ka 1664 0.0 1.0 0.062 0.187
protein_interaction rf 1664 0.0 0.895 0.029 0.068

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 0.904 0.139 0.192
integration_mean_by_presence el 1676 0.0 0.976 0.12 0.154
integration_mean_by_presence ka 1676 0.0 1.0 0.035 0.139
integration_mean_by_presence node2vec 1676 0.0 0.976 0.069 0.144
integration_mean_by_presence rf 1676 0.0 0.935 0.038 0.106
mean ct 1676 0.0 0.907 0.133 0.185
mean el 1676 0.0 0.936 0.109 0.142
mean ka 1676 0.0 1.0 0.033 0.14
mean node2vec 1676 0.0 0.959 0.052 0.13
mean rf 1676 0.0 0.909 0.035 0.098

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels